Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

Abstract Background In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene ( HBB ) may be a genetic factor responsible for these haematological changes during infection. However, the contributions of carriage different genotypes on remain largely unknown. Methodology this cross-sectional study, we evaluated abnormalities P. -infected children n = 217, aged 1–192 months) with (HbAA, HbAS HbSS). Children acute febrile were recruited at Jaramogi Oginga Odinga Teaching Referral Hospital outpatient clinic. Haematological parameters determined using Beckman Coulter counter ACTdiff2™ while genotyping was done TaqMan® SNP assay. Chi-square (χ 2 used to determine differences between proportions. Differences compared across groups Kruskal Wallis test Mann Whitney U test. Partial correlation sickle cell controlling age sex. Results Haemoglobin (Hb), [median (IQR); 7.3 (1.3), P 0.001], haematocrit (HCT), 26.4 (4.4), 0.009], red blood cells (RBC), 3.2 (1.7), 0.048] markedly reduced HbSS, however, distribution (RDW) 14.9 (3.3), 0.030] increased malaria infected HbSS. Severe anaemia highest HbSS (23.1%) followed by HbAA (8.6%) (7.1%). There no platelet count 0.399) hence severe thrombocytopeania genotypes. Leukocytosis (69.2%), 42% 31% HbAA. The RBC, HCT Hb had negative RDW malarial-infected r − 0.725, 0.008), 0.718, 0.009) 0.792, 0.002), respectively. Conclusion Our study reveals that is most common abnormality malaria-infected concentration decrease increase levels other Therefore, genotype correlated severity abnormalities.